Researchers have known that the peptide amyloid beta plays a role in causing Alzheimer’s disease, but they are still working to determine how it becomes toxic. Jan Bieschke, a biomedical engineer at Washington University in St. Louis, and collaborators in Germany have found that amyloid beta must change its internal structure into a long, flat structure called a beta sheet to be absorbed into the cell and become toxic. Results of the research were published Sept. 9 in the Journal of Biological Chemistry. Bieschke, assistant professor of biomedical engineering in the School of Engineering & Applied Science, and his collaborators found that the amyloid beta protein structure that was able penetrate the cell had a specific type of beta sheet in which its peptides stacked onto each other, similar to a layer cake. “Somewhere on this aggregation pathway, this type of structural element is formed for the amyloid beta to get into the cell,” Bieschke said. “There is a two-step process: amyloid beta can bind to the membrane and form aggregates while on the surface of the cell, then it gets taken up into the cell.”
Category: Natural Health
CALGARY, April 25, 2018 /PRNewswire/ – WestJet today issued the following statement regarding the Airline Pilots Association (ALPA) announcement that it has issued a strike authorization vote to WestJet pilots. “A strike authorization vote is a commo …
Category: Investing
April 26, 2018
La transformation numérique de l’aéroport s’accélère HANOVRE, Allemagne, 26 avril 2018 /PRNewswire/ — Lors de la Foire de Hanovre 2018, la plus grande foire industrielle au monde, Huawei, Telefónica Germany et …
Category: Investing
TAIPEI, Taiwan, April 25, 2018 /PRNewswire/ — UBM Taiwan and Council of Agriculture (COA) collectively launch 2018 Asia Agri-Tech Expo & Forum at Taipei World Trade Center from July 26-28. Themed “innovative, eco-friendly, sustainable,” the …
Category: Investing
April 26, 2018
SAO PAULO, 26 april 2018 /PRNewswire/ — QMC Telecom International Holdings, LLC (“QMC”), een toonaangevende onafhankelijke eigenaar en operator van draadloze communicatie-infrastructuur in Latijns-Amerika, heeft aangekondigd dat het bedrijf een …
Category: Investing
LOS ANGELES, April 25, 2018 /PRNewswire-USNewswire/ — Gail Abarbanel, founder and director of the Rape Treatment Center and Stuart House at Santa Monica-UCLA Medical Center, received an honorary Doctor of Humane Letters degree from Loyola Marym …
Category: Investing
-Huawei en Ecosystem Partners houden mondiale FSI-top in Beijing BEIJING, 26 april 2018 /PRNewswire/ — Huawei heeft vandaag de top inzake de mondiale sector van de financiële dienstverlening (FSI, Financial Services Industry) gehouden met als t …
Category: Investing
CALGARY, April 25, 2018 /PRNewswire/ – WestJet today issued the following statement regarding the Airline Pilots Association (ALPA) announcement that it has issued a strike authorization vote to WestJet pilots. “A strike authorization vote is a commo …
Category: Investing
April 26, 2018
La transformation numérique de l’aéroport s’accélère HANOVRE, Allemagne, 26 avril 2018 /PRNewswire/ — Lors de la Foire de Hanovre 2018, la plus grande foire industrielle au monde, Huawei, Telefónica Germany et …
Category: Investing
TAIPEI, Taiwan, April 25, 2018 /PRNewswire/ — UBM Taiwan and Council of Agriculture (COA) collectively launch 2018 Asia Agri-Tech Expo & Forum at Taipei World Trade Center from July 26-28. Themed “innovative, eco-friendly, sustainable,” the …
Category: Investing
April 26, 2018
SAO PAULO, 26 april 2018 /PRNewswire/ — QMC Telecom International Holdings, LLC (“QMC”), een toonaangevende onafhankelijke eigenaar en operator van draadloze communicatie-infrastructuur in Latijns-Amerika, heeft aangekondigd dat het bedrijf een …
Category: Investing
LOS ANGELES, April 25, 2018 /PRNewswire-USNewswire/ — Gail Abarbanel, founder and director of the Rape Treatment Center and Stuart House at Santa Monica-UCLA Medical Center, received an honorary Doctor of Humane Letters degree from Loyola Marym …
Category: Investing
-Huawei en Ecosystem Partners houden mondiale FSI-top in Beijing BEIJING, 26 april 2018 /PRNewswire/ — Huawei heeft vandaag de top inzake de mondiale sector van de financiële dienstverlening (FSI, Financial Services Industry) gehouden met als t …
Category: Investing
Think of canning as a precision form of cooking. When canning, you will use ordinary kitchen skills but must observe instructions exactly to ensure that the food is sterilized and safe. This is one time when you definitely shouldn’t improvise. Select Jars and Lids Use mason-type jars, which come in a variety of sizes. Pints and quarts are common and suitable for most canning. Choose from easy-to-fill wide-mouthed jars or traditional-looking narrow-mouthed jars. You can either start with new jars or recycle previously used but still perfect (no cracks or chips) canning jars. Avoid mayo jars and other kinds of glass containers because they may not hold up to processing. The lids used for canning consist of two pieces–a flat metal disk (rimmed with a rubber gasket) that covers the jar opening, and a screw-on band that holds the disk in place. Always use new flat metal disks because the gasket around each rim can begin to deteriorate after sitting in storage for 5 or more years; consequently, it may fail to seal. You can reuse screw-on bands, though, as long as they look good and have no rust.
Category: Gardening
CALGARY, April 25, 2018 /PRNewswire/ – WestJet today issued the following statement regarding the Airline Pilots Association (ALPA) announcement that it has issued a strike authorization vote to WestJet pilots. “A strike authorization vote is a commo …
Category: Investing
April 26, 2018
La transformation numérique de l’aéroport s’accélère HANOVRE, Allemagne, 26 avril 2018 /PRNewswire/ — Lors de la Foire de Hanovre 2018, la plus grande foire industrielle au monde, Huawei, Telefónica Germany et …
Category: Investing
TAIPEI, Taiwan, April 25, 2018 /PRNewswire/ — UBM Taiwan and Council of Agriculture (COA) collectively launch 2018 Asia Agri-Tech Expo & Forum at Taipei World Trade Center from July 26-28. Themed “innovative, eco-friendly, sustainable,” the …
Category: Investing
April 26, 2018
SAO PAULO, 26 april 2018 /PRNewswire/ — QMC Telecom International Holdings, LLC (“QMC”), een toonaangevende onafhankelijke eigenaar en operator van draadloze communicatie-infrastructuur in Latijns-Amerika, heeft aangekondigd dat het bedrijf een …
Category: Investing
LOS ANGELES, April 25, 2018 /PRNewswire-USNewswire/ — Gail Abarbanel, founder and director of the Rape Treatment Center and Stuart House at Santa Monica-UCLA Medical Center, received an honorary Doctor of Humane Letters degree from Loyola Marym …
Category: Investing
-Huawei en Ecosystem Partners houden mondiale FSI-top in Beijing BEIJING, 26 april 2018 /PRNewswire/ — Huawei heeft vandaag de top inzake de mondiale sector van de financiële dienstverlening (FSI, Financial Services Industry) gehouden met als t …
Category: Investing
WILMINGTON, Del., April 25, 2018 /PRNewswire/ — Principals in Sport Trinity LLC, the largest investor in BIG3 Basketball, LLC, today filed a motion for the removal to the Federal Court in Los Angeles of the civil action previously brought in the Cal …
Category: Investing
HONG KONG, April 25, 2018 /PRNewswire/ — CNOOC Limited (the “Company”, NYSE: CEO, SEHK: 00883, TSX: CNU) announced on April 25, 2018 (New York time) the pricing of an offering of US$ 1,450,000,000 aggregate principal amount of guaranteed notes. The …
Category: Investing
April 26, 2018
SÃO PAULO, 25 de abril de 2018 /PRNewswire/ — A GOL Linhas Aéreas Inteligentes S.A. – (“GLAI”) (B3: GOLL4 e NYSE: GOL), a maior companhia aérea doméstica do Brasil, anuncia agenda de divulgação de resu …
Category: Investing
ALJ Acknowledges Need for the Project, but Route Recommendation Ignores State Analysis and Tribal Sovereignty CALGARY and HOUSTON, April 25, 2018 /PRNewswire/ – After review of the Minnesota Administrative Law Judge (ALJ) recommendation on the Line 3 …
Category: Investing
NEW YORK, April 25, 2018 /PRNewswire/ — Sutherland Asset Management Corporation (NYSE: SLD) (“Sutherland” or the “Company”) today announced that it priced an underwritten public offering of $50 million aggregate principal amount of its 6.50% Senior …
Category: Investing
April 26, 2018
SÃO PAULO, 25 de abril de 2018 /PRNewswire/ — A Azul lança hoje a edição 2017 de seu Relatório de Responsabilidade Social, documento que reúne as principais ações sociais, de voluntariado …
Category: Investing