Researchers have known that the peptide amyloid beta plays a role in causing Alzheimer’s disease, but they are still working to determine how it becomes toxic. Jan Bieschke, a biomedical engineer at Washington University in St. Louis, and collaborators in Germany have found that amyloid beta must change its internal structure into a long, flat structure called a beta sheet to be absorbed into the cell and become toxic. Results of the research were published Sept. 9 in the Journal of Biological Chemistry. Bieschke, assistant professor of biomedical engineering in the School of Engineering & Applied Science, and his collaborators found that the amyloid beta protein structure that was able penetrate the cell had a specific type of beta sheet in which its peptides stacked onto each other, similar to a layer cake. “Somewhere on this aggregation pathway, this type of structural element is formed for the amyloid beta to get into the cell,” Bieschke said. “There is a two-step process: amyloid beta can bind to the membrane and form aggregates while on the surface of the cell, then it gets taken up into the cell.”
Category: Natural Health
SANDVIKEN, Sweden, May 22, 2019 /PRNewswire/ — Today, at the Capital Markets Day in Tampere, Finland, Björn Rosengren, President and CEO of Sandvik andTomas Eliasson, Executive Vice President and CFO of Sandvik, will present the key strategic f …
Category: Investing
NANCHANG, China, May 21, 2019 /PRNewswire/ — The Expo Central China 2019 has seen 406 projects signed in six provinces of central China with a total amount of 483.513 billion yuan as global investors seek to tap the growth potential of the country’s …
Category: Investing
LONDRES, 22 mai 2019 /PRNewswire/ — La finale de la Ligue Europa, qui opposera les équipes d’Arsenal et Chelsea le 29 mai 2019, se disputera à Bakou. Suite à la confirmation aujourd’hui par le joueur d’Arsenal Henrikh Mkhitaryan …
Category: Investing
ZÜRICH, 22. Mai 2019 /PRNewswire/ — Ein Vergleich der langen Innovationsgeschichte der Schweiz und der sich abzeichnenden globalen Anerkennung Chinas als wichtiger Akteur für innovative Prozesse und Produkte bildete den Rahmen für leb …
Category: Investing
VALENCIA, Calif., May 21, 2019 /PRNewswire/ — “In the complex world of healthcare benefits, members want an easy and quick answer to their most pressing questions. Instead of calling in or searching online, our smart assistant follows this trend and …
Category: Investing
CIUDAD DE MÉXICO, 21 de mayo de 2019 /PRNewswire/ — En este 25 aniversario en México, Sony festeja en grande y pone el ambiente en todas las fiestas, con el lanzamiento de su nueva línea de sistemas de audio de alta potencia par …
Category: Investing
SANDVIKEN, Sweden, May 22, 2019 /PRNewswire/ — Today, at the Capital Markets Day in Tampere, Finland, Björn Rosengren, President and CEO of Sandvik andTomas Eliasson, Executive Vice President and CFO of Sandvik, will present the key strategic f …
Category: Investing
NANCHANG, China, May 21, 2019 /PRNewswire/ — The Expo Central China 2019 has seen 406 projects signed in six provinces of central China with a total amount of 483.513 billion yuan as global investors seek to tap the growth potential of the country’s …
Category: Investing
LONDRES, 22 mai 2019 /PRNewswire/ — La finale de la Ligue Europa, qui opposera les équipes d’Arsenal et Chelsea le 29 mai 2019, se disputera à Bakou. Suite à la confirmation aujourd’hui par le joueur d’Arsenal Henrikh Mkhitaryan …
Category: Investing
ZÜRICH, 22. Mai 2019 /PRNewswire/ — Ein Vergleich der langen Innovationsgeschichte der Schweiz und der sich abzeichnenden globalen Anerkennung Chinas als wichtiger Akteur für innovative Prozesse und Produkte bildete den Rahmen für leb …
Category: Investing
VALENCIA, Calif., May 21, 2019 /PRNewswire/ — “In the complex world of healthcare benefits, members want an easy and quick answer to their most pressing questions. Instead of calling in or searching online, our smart assistant follows this trend and …
Category: Investing
CIUDAD DE MÉXICO, 21 de mayo de 2019 /PRNewswire/ — En este 25 aniversario en México, Sony festeja en grande y pone el ambiente en todas las fiestas, con el lanzamiento de su nueva línea de sistemas de audio de alta potencia par …
Category: Investing
(NaturalNews) Although some still regard prepping to be an activity favored by survivalist “wackos” who fear a cataclysmic Armageddon-style event, more and more American families are beginning to see the value in preparing for a number of possible scenarios in which the stockpiling of food, water and other essentials could prove to be a very wise investment. The Oxford Dictionary defines “prepping” (in this usage of the term) as: The practice of making active preparations for a possible catastrophic disaster or emergency, typically by stockpiling food, ammunition, and other supplies. Prepping runs the gamut from weather events to armageddon In practice, prepping can range from simply making sure a household has enough basic supplies to survive a temporary power outage or major weather event – such as a hurricane – to preparing for a long-term crisis, such as a massive power grid failure.
Category: General
SANDVIKEN, Sweden, May 22, 2019 /PRNewswire/ — Today, at the Capital Markets Day in Tampere, Finland, Björn Rosengren, President and CEO of Sandvik andTomas Eliasson, Executive Vice President and CFO of Sandvik, will present the key strategic f …
Category: Investing
NANCHANG, China, May 21, 2019 /PRNewswire/ — The Expo Central China 2019 has seen 406 projects signed in six provinces of central China with a total amount of 483.513 billion yuan as global investors seek to tap the growth potential of the country’s …
Category: Investing
LONDRES, 22 mai 2019 /PRNewswire/ — La finale de la Ligue Europa, qui opposera les équipes d’Arsenal et Chelsea le 29 mai 2019, se disputera à Bakou. Suite à la confirmation aujourd’hui par le joueur d’Arsenal Henrikh Mkhitaryan …
Category: Investing
ZÜRICH, 22. Mai 2019 /PRNewswire/ — Ein Vergleich der langen Innovationsgeschichte der Schweiz und der sich abzeichnenden globalen Anerkennung Chinas als wichtiger Akteur für innovative Prozesse und Produkte bildete den Rahmen für leb …
Category: Investing
VALENCIA, Calif., May 21, 2019 /PRNewswire/ — “In the complex world of healthcare benefits, members want an easy and quick answer to their most pressing questions. Instead of calling in or searching online, our smart assistant follows this trend and …
Category: Investing
CIUDAD DE MÉXICO, 21 de mayo de 2019 /PRNewswire/ — En este 25 aniversario en México, Sony festeja en grande y pone el ambiente en todas las fiestas, con el lanzamiento de su nueva línea de sistemas de audio de alta potencia par …
Category: Investing
HARRISBURG, Pa., May 21, 2019 /PRNewswire/ — An hour after Pennsylvania’s polling places closed, Acting Secretary of State Kathy Boockvar reported no major problems or incidents during today’s primary election. “Fair weather across the commonwealth …
Category: Investing
SAN FRANCISCO, May 21, 2019 /PRNewswire/ — Stilt, a mission-driven company focused on democratizing access to credit for immigrants and international students, today announced its partnership with Remitly, the largest independent digital remittance …
Category: Investing
CALVERTON, Md., May 21, 2019 /PRNewswire/ — Potomac Financial Group (PFG), a Maryland-based provider of financial planning and wealth management services, recently announced the launch of Freedom7, a proprietary 7-step financial planning process. De …
Category: Investing
BERLIN, May 21, 2019 /PRNewswire/ — On Tuesday, May 21, international advocacy organization Global Citizen hosted an impactful evening at Berlin’s Tempodrom, with leaders from across Germany and Africa making meaningful commitments towards ending ex …
Category: Investing
TOKYO, May 21, 2019 /PRNewswire/ — Up-and-coming Japanese real estate developer Global Agents Co. Ltd has just announced the grand opening of the third location of their luxury capsule hotel brand ‘The Millennials’. The first two locations in Kyoto …
Category: Investing
NEW YORK, May 21, 2019 /PRNewswire/ — The International Center for Journalists (ICFJ) announced the lineup for its 35th Anniversary Awards Dinner on Nov. 7 in Washington, DC. The honorees include three courageous journalists: CBS News correspondent …
Category: Investing