Researchers have known that the peptide amyloid beta plays a role in causing Alzheimer’s disease, but they are still working to determine how it becomes toxic. Jan Bieschke, a biomedical engineer at Washington University in St. Louis, and collaborators in Germany have found that amyloid beta must change its internal structure into a long, flat structure called a beta sheet to be absorbed into the cell and become toxic. Results of the research were published Sept. 9 in the Journal of Biological Chemistry. Bieschke, assistant professor of biomedical engineering in the School of Engineering & Applied Science, and his collaborators found that the amyloid beta protein structure that was able penetrate the cell had a specific type of beta sheet in which its peptides stacked onto each other, similar to a layer cake. “Somewhere on this aggregation pathway, this type of structural element is formed for the amyloid beta to get into the cell,” Bieschke said. “There is a two-step process: amyloid beta can bind to the membrane and form aggregates while on the surface of the cell, then it gets taken up into the cell.”
Category: Natural Health
Mr. Mello brings more than 11 years of banking experience, covering business lending, small business client acquisition and branch management. Most recently, he served as Vice President, Relationship Manager of Commercial Banking for Banc of Californ …
Category: Investing
ST. LOUIS, Dec. 19, 2018 /PRNewswire/ — Centene Corporation (NYSE: CNC) announced today it will present at the 37th Annual J. P. Morgan Healthcare Conference, to be held January 7-10, 2019, at the Westin St. Francis Hotel. Centene will present on Mo …
Category: Investing
HERZLIYA, Israel, Dec. 19, 2018 /PRNewswire/ — Safe-T® (NASDAQ: SFET) (TASE: SFET), a leading provider of Software-defined Access (SDA) solutions for the hybrid cloud, today announced the availability of the newest version of the company’s …
Category: Investing
DENVER, Dec. 19, 2018 /PRNewswire/ — ProtectWise, the leader in Cloud-delivered Network Detection and Response (NDR), today released a new report, “The State of AI in Cybersecurity — The Benefits, Limitations and Evolving Questions.” Cond …
Category: Investing
Mr. Mello brings more than 11 years of banking experience, covering business lending, small business client acquisition and branch management. Most recently, he served as Vice President, Relationship Manager of Commercial Banking for Banc of Californ …
Category: Investing
ST. LOUIS, Dec. 19, 2018 /PRNewswire/ — Centene Corporation (NYSE: CNC) announced today it will present at the 37th Annual J. P. Morgan Healthcare Conference, to be held January 7-10, 2019, at the Westin St. Francis Hotel. Centene will present on Mo …
Category: Investing
HERZLIYA, Israel, Dec. 19, 2018 /PRNewswire/ — Safe-T® (NASDAQ: SFET) (TASE: SFET), a leading provider of Software-defined Access (SDA) solutions for the hybrid cloud, today announced the availability of the newest version of the company’s …
Category: Investing
DENVER, Dec. 19, 2018 /PRNewswire/ — ProtectWise, the leader in Cloud-delivered Network Detection and Response (NDR), today released a new report, “The State of AI in Cybersecurity — The Benefits, Limitations and Evolving Questions.” Cond …
Category: Investing
It is a month after Britain’s surprise vote to leave the EU. A new Conservative Prime Minister and Chancellor are in place, both David Cameron and George Osborne having fallen on their swords. The third man in the losing triumvirate, Mark Carney, is still in office. Having taken a political stance in the pre-referendum debate, there can be little doubt the post-referendum fall in sterling was considerably greater than if he had kept on the side-lines. This article takes to task the Treasury’s estimates of the effect of Brexit on the British economy and Mr Carney’s role in the affair, then assesses the actual consequences. The Treasury’s economic weapons of mass destruction One of the Treasury’s models predicted Brexit would cost each household £4,300 every year. There were at least two things wrong with this prediction. Firstly, it was presented as if it was a loss of net income, in other words the business profit or wages the average household would lose. The estimate was nothing of the sort, it was the Treasury’s estimate of the loss of annual GDP divided by the number of households in the event of Brexit.
Category: Gold
Mr. Mello brings more than 11 years of banking experience, covering business lending, small business client acquisition and branch management. Most recently, he served as Vice President, Relationship Manager of Commercial Banking for Banc of Californ …
Category: Investing
ST. LOUIS, Dec. 19, 2018 /PRNewswire/ — Centene Corporation (NYSE: CNC) announced today it will present at the 37th Annual J. P. Morgan Healthcare Conference, to be held January 7-10, 2019, at the Westin St. Francis Hotel. Centene will present on Mo …
Category: Investing
HERZLIYA, Israel, Dec. 19, 2018 /PRNewswire/ — Safe-T® (NASDAQ: SFET) (TASE: SFET), a leading provider of Software-defined Access (SDA) solutions for the hybrid cloud, today announced the availability of the newest version of the company’s …
Category: Investing
DENVER, Dec. 19, 2018 /PRNewswire/ — ProtectWise, the leader in Cloud-delivered Network Detection and Response (NDR), today released a new report, “The State of AI in Cybersecurity — The Benefits, Limitations and Evolving Questions.” Cond …
Category: Investing
NEW YORK, Dec. 19, 2018 /PRNewswire/ — gyro, the world’s first full-service global creative B2B powerhouse, today announced it was named to the 2019 Chief Marketer 200 (CM200) list of the country’s top 200 non-advertising agencies serving the U …
Category: Investing
NORWALK, Conn., Dec. 19, 2018 /PRNewswire/ — 365 Data Centers, a leading provider of hybrid data center services for carrier, content and enterprise customers, today announces major upgrades to its network infrastructure in Southeast Florida. The up …
Category: Investing
HOUSTON, Dec. 19, 2018 /PRNewswire/ — Pelican Energy Partners (“Pelican”) is pleased to announce it has partnered with Keith Klopfenstein and Gus Halas and completed an investment in Axon Pressure Products, Inc. (“Axon”), an independent manufac …
Category: Investing
SOMERVILLE, Mass., Dec. 19, 2018 /PRNewswire/ — Evergage, The 1-to-1 Platform company, today announced continued uptake and momentum for its award-winning, advanced email personalization solutions. Evergage for Email customers have increased by …
Category: Investing
FLINT, Mich., Dec. 19, 2018 /PRNewswire/ — Diplomat Pharmacy, Inc. (NYSE: DPLO), executives will present at this year’s J.P. Morgan Healthcare Conference in San Francisco. Diplomat’s Brian Griffin, chairman and CEO, and Atul Kavt …
Category: Investing